PDBe 2bug

Solution NMR

Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide

Released:

Function and Biology Details

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein phosphatase 5 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53041 (Residues: 18-147; Coverage: 26%)
Gene names: PPP5, PPP5C
Sequence domains: Tetratricopeptide repeat
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Heat shock protein HSP 90-alpha Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 648 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P07900 (Residues: 728-732; Coverage: 1%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: ARIA
Chemical shifts: BMR6696  
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided