PDBe 2bu6

X-ray diffraction
2.4Å resolution

crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.65 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15119 (Residues: 14-407; Coverage: 97%)
  • Best match: Q15119-2 (Residues: 1-343)
Gene names: PDHK2, PDK2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P64
Unit cell:
a: 108.873Å b: 108.873Å c: 84.202Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.247 0.261
Expression system: Trichoplusia ni