PDBe 2brq

X-ray diffraction
2.1Å resolution

Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Filamin-A Chains: A, B
Molecule details ›
Chains: A, B
Length: 97 amino acids
Theoretical weight: 9.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21333 (Residues: 2236-2329; Coverage: 4%)
Gene names: FLN, FLN1, FLNA
Structure domains: Immunoglobulins
Integrin beta-7 Chains: C, D
Molecule details ›
Chains: C, D
Length: 31 amino acids
Theoretical weight: 3.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P26010 (Residues: 768-798; Coverage: 4%)
Gene name: ITGB7

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 41.97Å b: 60Å c: 51.57Å
α: 90° β: 110.17° γ: 90°
R-values:
R R work R free
0.197 0.192 0.243
Expression systems:
  • Escherichia coli BL21
  • Not provided