PDBe 2bme

X-ray diffraction
1.57Å resolution

high resolution structure of GppNHp-bound human Rab4a

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Ras-related protein Rab-4A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 186 amino acids
Theoretical weight: 20.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P20338 (Residues: 6-189; Coverage: 84%)
Gene names: RAB4, RAB4A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P43
Unit cell:
a: 99.79Å b: 99.79Å c: 95.54Å
α: 90° β: 90° γ: 90°
R R work R free
0.194 0.192 0.229
Expression system: Escherichia coli BL21(DE3)