PDBe 2bck

X-ray diffraction
2.8Å resolution

Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero hexamer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A-24 alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 294 amino acids
Theoretical weight: 33.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05534 (Residues: 25-300; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Telomerase reverse transcriptase Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14746 (Residues: 461-469; Coverage: 1%)
Gene names: EST2, TCS1, TERT, TRT

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: C2
Unit cell:
a: 125.505Å b: 132.186Å c: 91.197Å
α: 90° β: 128.8° γ: 90°
R-values:
R R work R free
0.187 0.183 0.256
Expression systems:
  • Escherichia coli
  • Not provided