PDBe 2b3l

X-ray diffraction
1.5Å resolution

Crystal structure of type I human methionine aminopeptidase in the apo form


Function and Biology Details

Reaction catalysed:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Methionine aminopeptidase 1 Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 36.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: NEW P53582 (Residues: 81-384; Coverage: 79%)
Gene names: KIAA0094, METAP1
Sequence domains: Metallopeptidase family M24
Structure domains: Creatinase/methionine aminopeptidase superfamily

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21
Unit cell:
a: 47.217Å b: 77.276Å c: 47.85Å
α: 90° β: 91.59° γ: 90°
R R work R free
0.122 0.117 0.18
Expression system: Escherichia coli BL21(DE3)