PDBe 2aw5

X-ray diffraction
2.5Å resolution

Crystal structure of a human malic enzyme

Released:
Source organism: Homo sapiens
Entry authors: Papagrigoriou E, Berridge G, Smee C, Bray J, Arrowsmith C, Edwards A, Weigelt J, Sundstrom M, Oppermann U, Gileadi O, von Delft F, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NADP-dependent malic enzyme Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 575 amino acids
Theoretical weight: 64.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48163 (Residues: 13-564; Coverage: 97%)
Gene name: ME1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 152.505Å b: 136.963Å c: 117.84Å
α: 90° β: 121.75° γ: 90°
R-values:
R R work R free
0.21 0.207 0.256
Expression system: Escherichia coli