PDBe 2ain

Solution NMR

Solution structure of the AF-6 PDZ domain complexed with the C-terminal peptide from the Bcr protein

Released:
Source organism: Homo sapiens
Primary publication:
Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex.
Protein Sci. 16 1053-62 (2007)
PMID: 17473018

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Afadin Chain: A
Molecule details ›
Chain: A
Length: 93 amino acids
Theoretical weight: 9.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55196 (Residues: 1003-1094; Coverage: 5%)
Gene names: AF6, AFDN, MLLT4
Sequence domains: PDZ domain (Also known as DHR or GLGF)
Structure domains: Pdz3 Domain
Breakpoint cluster region protein Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 695 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P11274 (Residues: 1266-1271; Coverage: 1%)
Gene names: BCR, BCR1, D22S11

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, molecular dynamics, torsion angle dynamics
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided