PDBe 2a24

Solution NMR

HADDOCK Structure of HIF-2a/ARNT PAS-B Heterodimer

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Endothelial PAS domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99814 (Residues: 242-348; Coverage: 12%)
Gene names: BHLHE73, EPAS1, HIF2A, MOP2, PASD2
Sequence domains: PAS fold
Structure domains: Beta-Lactamase
Aryl hydrocarbon receptor nuclear translocator Chain: B
Molecule details ›
Chain: B
Length: 108 amino acids
Theoretical weight: 12.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P27540 (Residues: 358-465; Coverage: 14%)
Gene names: ARNT, BHLHE2
Structure domains: Beta-Lactamase

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing