PDBe 2a0q

X-ray diffraction
1.9Å resolution

Structure of thrombin in 400 mM potassium chloride

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombin light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 30 amino acids
Theoretical weight: 3.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 334-363; Coverage: 5%)
Gene name: F2
Thrombin heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 257 amino acids
Theoretical weight: 29.51 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-620; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 58.51Å b: 69.74Å c: 158.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.195 0.24
Expression system: Cricetulus griseus