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Crystal structure of a group I intron/two exon complex that includes all catalytic metal ion ligands.

X-ray diffraction
3.37Å resolution
PDB entry 1zzn coloured by chain, front view.
PDB entry 1zzn coloured by chain, side view.
PDB entry 1zzn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
3 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: U1 small nuclear ribonucleoprotein A and RNA
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Multimeric state: hetero tetramer
Accessible surface area: 36813.09 Å2
Buried surface area: 8889.89 Å2
Dissociation area: 898.76 Å2
Dissociation energy (ΔGdiss): 4.9 kcal/mol
Dissociation entropy (TΔSdiss): 11.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140476

Macromolecules

U1 small nuclear ribonucleoprotein A
Chain: A
Length: 98 amino acids
Theoretical weight: 11.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09012 (Residues: 1-98; Coverage: 35%)
Gene name: SNRPA
Pfam: RNA recognition motif
InterPro:
CATH: Alpha-Beta Plaits
SCOP: Canonical RBD
U1 small nuclear ribonucleoprotein A in PDB entry 1zzn, assembly 1, front view.
U1 small nuclear ribonucleoprotein A in PDB entry 1zzn, assembly 1, side view.
U1 small nuclear ribonucleoprotein A in PDB entry 1zzn, assembly 1, top view.
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RNA chain B
Name: 197-MER
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 197 nucleotides
Theoretical weight: 64.06 KDa
197-MER in PDB entry 1zzn, assembly 1, front view.
197-MER in PDB entry 1zzn, assembly 1, side view.
197-MER in PDB entry 1zzn, assembly 1, top view.
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RNA chain C
Name: 5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*GP*AP*CP*GP*GP*CP*C)-3'
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 22 nucleotides
Theoretical weight: 7.05 KDa
5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*GP*AP*CP*GP*GP*CP*C)-3' in PDB entry 1zzn, assembly 1, front view.
5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*GP*AP*CP*GP*GP*CP*C)-3' in PDB entry 1zzn, assembly 1, side view.
5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*GP*AP*CP*GP*GP*CP*C)-3' in PDB entry 1zzn, assembly 1, top view.
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RNA chain D
Name: 5'-R(*CP*AP*(5MU))-3'
Representative chains: D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 3 nucleotides
Theoretical weight: 910 Da
5'-R(*CP*AP*(5MU))-3' in PDB entry 1zzn, assembly 1, front view.
5'-R(*CP*AP*(5MU))-3' in PDB entry 1zzn, assembly 1, side view.
5'-R(*CP*AP*(5MU))-3' in PDB entry 1zzn, assembly 1, top view.
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