PDBe 1zxe

X-ray diffraction
2.6Å resolution

Crystal Structure of eIF2alpha Protein Kinase GCN2: D835N Inactivating Mutant in Apo Form


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
eIF-2-alpha kinase GCN2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 303 amino acids
Theoretical weight: 35.56 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
  • Canonical: P15442 (Residues: 594-997; Coverage: 18%)
Gene names: AAS1, GCN2, YDR283C
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 79.56Å b: 154.14Å c: 157.35Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.204 0.252
Expression system: Escherichia coli