PDBe 1zuc

X-ray diffraction
2Å resolution

Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P06401 (Residues: 676-933; Coverage: 28%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 57.519Å b: 64.497Å c: 70.406Å
α: 90° β: 95.76° γ: 90°
R R work R free
0.181 0.179 0.228
Expression system: Escherichia coli BL21