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Crystal Structure of Chorismate Synthase from Mycobacterium tuberculosis

X-ray diffraction
2.65Å resolution
PDB entry 1ztb coloured by chain, front view.
PDB entry 1ztb coloured by chain, side view.
PDB entry 1ztb coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Chorismate synthase
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Multimeric state: monomeric
Accessible surface area: 17805.42 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-162022
Assembly 2
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Assembly Name: Chorismate synthase
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Multimeric state: homo tetramer
Accessible surface area: 45290.72 Å2
Buried surface area: 25926.57 Å2
Dissociation area: 5,163.82 Å2
Dissociation energy (ΔGdiss): 51.49 kcal/mol
Dissociation entropy (TΔSdiss): 16.08 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-162024

Macromolecules

Chorismate synthase
Chain: A
Length: 401 amino acids
Theoretical weight: 41.84 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPY1 (Residues: 1-401; Coverage: 100%)
Gene names: MTCY159.16, Rv2540c, aroC, aroF
Pfam: Chorismate synthase
InterPro:
CATH: Chorismate synthase AroC
Chorismate synthase in PDB entry 1ztb, assembly 1, front view.
Chorismate synthase in PDB entry 1ztb, assembly 1, side view.
Chorismate synthase in PDB entry 1ztb, assembly 1, top view.
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