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Factor XI complexed with a pyrimidinone inhibitor

X-ray diffraction
2.05Å resolution
PDB entry 1zsl coloured by chain, front view.
PDB entry 1zsl coloured by chain, side view.
PDB entry 1zsl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor XIa light chain
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Multimeric state: monomeric
Accessible surface area: 11052.17 Å2
Buried surface area: 1002.81 Å2
Dissociation area: 501.4 Å2
Dissociation energy (ΔGdiss): 11.85 kcal/mol
Dissociation entropy (TΔSdiss): 5.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137278

Macromolecules

Coagulation factor XIa light chain
Chain: A
Length: 238 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Coagulation factor XIa light chain in PDB entry 1zsl, assembly 1, front view.
Coagulation factor XIa light chain in PDB entry 1zsl, assembly 1, side view.
Coagulation factor XIa light chain in PDB entry 1zsl, assembly 1, top view.
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