Function and Biology

beta PIX-SH3 complexed with an atypical peptide from alpha-PAK

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein.
Comments:
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • Beta-adrenergic receptor kinase
  • Beta-IIPKC
  • Epsilon PKC
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • CK-2
  • CKI
  • CKII
  • Hpr kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • PKA
  • PKC
  • Raf kinase
  • Raf-1
  • T-antigen kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • Hydroxyalkyl-protein kinase
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • Phosphorylase B kinase kinase
  • Glycogen synthase A kinase
  • HIPK2
  • Wee 1-like kinase
  • WEE1Hu
  • Prp4 protein kinase
  • Dsk1
  • STK32
  • Wee-kinase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF07653
Domain description: Variant SH3 domain
Occurring in:
  1. Rho guanine nucleotide exchange factor 7
1 copy of Pfam domain PF07653 (Variant SH3 domain) in Rho guanine nucleotide exchange factor 7 in PDB 1zsg.

InterPro InterPro annotations
IPR001452
Domain description: SH3 domain
Occurring in:
  1. Rho guanine nucleotide exchange factor 7
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. Rho guanine nucleotide exchange factor 7
IPR035789
Domain description: Rho guanine nucleotide exchange factor 7, SH3 domain
Occurring in:
  1. Rho guanine nucleotide exchange factor 7

Structure domain

CATH CATH domain
2.30.30.40
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 Domains
Occurring in:
  1. Rho guanine nucleotide exchange factor 7
1 copy of CATH domain 2.30.30.40 (SH3 type barrels.) in Rho guanine nucleotide exchange factor 7 in PDB 1zsg.