Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171569 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Rho guanine nucleotide exchange factor 7
Molecule details ›
Chain: A
Length: 65 amino acids
Theoretical weight: 7.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Length: 65 amino acids
Theoretical weight: 7.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q14155 (Residues: 179-243; Coverage: 8%)
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Serine/threonine-protein kinase PAK 1
Molecule details ›
Chain: B
Length: 22 amino acids
Theoretical weight: 2.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 22 amino acids
Theoretical weight: 2.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: Q13153 (Residues: 183-204; Coverage: 4%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
simluated annealing with torsion angle dynamics followed by Cartesian dynamics cooling
Expression systems:
- Escherichia coli BL21(DE3)
- Not provided
