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IRF-3 releases its inhibitions.

Hiscott J, Lin R
Structure 13 1235-6 (2005)
Cited: 33 times
EuropePMC logo PMID: 16154077

Abstract

Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.

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  2. Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum. Burger VM, Nolasco DO, Stultz CM. J Biol Chem 291 6706-6713 (2016)

Articles - 1zoq mentioned but not cited (22)

  1. Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP. Kjaergaard M, Teilum K, Poulsen FM. Proc Natl Acad Sci U S A 107 12535-12540 (2010)
  2. Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Zhao B, Shu C, Gao X, Sankaran B, Du F, Shelton CL, Herr AB, Ji JY, Li P. Proc Natl Acad Sci U S A 113 E3403-12 (2016)
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  5. Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model. Knott M, Best RB. J Chem Phys 140 175102 (2014)
  6. New insight into Alzheimer's disease: Light reverses Aβ-obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice. Yue X, Mei Y, Zhang Y, Tong Z, Cui D, Yang J, Wang A, Wang R, Fei X, Ai L, Di Y, Luo H, Li H, Luo W, Lu Y, Li R, Duan C, Gao G, Yang H, Sun B, He R, Song W, Han H, Tong Z. Alzheimers Dement (N Y) 5 671-684 (2019)
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  8. The Protein Structure Context of PolyQ Regions. Totzeck F, Andrade-Navarro MA, Mier P. PLoS One 12 e0170801 (2017)
  9. Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3). Bergstroem B, Johnsen IB, Nguyen TT, Hagen L, Slupphaug G, Thommesen L, Anthonsen MW. J Biol Chem 285 24904-24914 (2010)
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  11. Is a malleable protein necessarily highly dynamic? The hydrophobic core of the nuclear coactivator binding domain is well ordered. Kjaergaard M, Poulsen FM, Teilum K. Biophys J 102 1627-1635 (2012)
  12. The interaction between the measles virus nucleoprotein and the Interferon Regulator Factor 3 relies on a specific cellular environment. Colombo M, Bourhis JM, Chamontin C, Soriano C, Villet S, Costanzo S, Couturier M, Belle V, Fournel A, Darbon H, Gerlier D, Longhi S. Virol J 6 59 (2009)
  13. Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs. Papaleo E, Camilloni C, Teilum K, Vendruscolo M, Lindorff-Larsen K. PeerJ 6 e5125 (2018)
  14. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. Bansode SB, Jana AK, Batkulwar KB, Warkad SD, Joshi RS, Sengupta N, Kulkarni MJ. PLoS One 9 e105196 (2014)
  15. The Effect of (-)-Epigallocatechin-3-Gallate on the Amyloid-β Secondary Structure. Acharya A, Stockmann J, Beyer L, Rudack T, Nabers A, Gumbart JC, Gerwert K, Batista VS. Biophys J 119 349-359 (2020)
  16. αB-Crystallin Chaperone Inhibits Aβ Aggregation by Capping the β-Sheet-Rich Oligomers and Fibrils. Sun Y, Ding F. J Phys Chem B 124 10138-10146 (2020)
  17. Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity. Anand BG, Wu Q, Karthivashan G, Shejale KP, Amidian S, Wille H, Kar S. Bioact Mater 6 4491-4505 (2021)
  18. Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ1-42. Hernández-Rodríguez M, Correa-Basurto J, Nicolás-Vázquez MI, Miranda-Ruvalcaba R, Benítez-Cardoza CG, Reséndiz-Albor AA, Méndez-Méndez JV, Rosales-Hernández MC. PLoS One 10 e0130263 (2015)
  19. Quasi-anharmonic analysis reveals intermediate states in the nuclear co-activator receptor binding domain ensemble. Burger VM, Ramanathan A, Savol AJ, Stanley CB, Agarwal PK, Chennubhotla CS. Pac Symp Biocomput 70-81 (2012)
  20. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)
  21. Implications of the Essential Role of Small Molecule Ligand Binding Pockets in Protein-Protein Interactions. Skolnick J, Zhou H. J Phys Chem B 126 6853-6867 (2022)
  22. Ameliorating amyloid aggregation through osmolytes as a probable therapeutic molecule against Alzheimer's disease and type 2 diabetes. Kumari A, Somvanshi P, Grover A. RSC Adv 10 12166-12182 (2020)


Reviews citing this publication (3)

  1. The role of differential expression of human interferon--a genes in antiviral immunity. Génin P, Vaccaro A, Civas A. Cytokine Growth Factor Rev 20 283-295 (2009)
  2. Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. Solis M, Goubau D, Romieu-Mourez R, Genin P, Civas A, Hiscott J. Biochem Pharmacol 72 1469-1476 (2006)
  3. Specificity and Function of IRF Family Transcription Factors: Insights from Genomics. Mancino A, Natoli G. J Interferon Cytokine Res 36 462-469 (2016)

Articles citing this publication (6)

  1. Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function. Rengachari S, Groiss S, Devos JM, Caron E, Grandvaux N, Panne D. Proc Natl Acad Sci U S A 115 E601-E609 (2018)
  2. DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation. Kim SS, Lee KG, Chin CS, Ng SK, Pereira NA, Xu S, Lam KP. J Immunol 193 840-848 (2014)
  3. I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T. EMBO J 32 816-828 (2013)
  4. MiR-139 Induces an Interferon-β Response in Prostate Cancer Cells by Binding to RIG-1. Nam RK, Benatar T, Amemiya Y, Seth A. Cancer Genomics Proteomics 18 197-206 (2021)
  5. The Structural Basis of IRF-3 Activation upon Phosphorylation. Jing T, Zhao B, Xu P, Gao X, Chi L, Han H, Sankaran B, Li P. J Immunol 205 1886-1896 (2020)
  6. Mapping the transition state for a binding reaction between ancient intrinsically disordered proteins. Karlsson E, Paissoni C, Erkelens AM, Tehranizadeh ZA, Sorgenfrei FA, Andersson E, Ye W, Camilloni C, Jemth P. J Biol Chem 295 17698-17712 (2020)


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