PDBe 1zlt

X-ray diffraction
1.74Å resolution

Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog

Source organism: Homo sapiens
Entry authors: Lee CC, Ng K, Wan Y, Gray N, Spraggon G

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 33.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O14757 (Residues: 1-289; Coverage: 61%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 45Å b: 65.643Å c: 58.112Å
α: 90° β: 94.71° γ: 90°
R R work R free
0.227 0.227 0.265
Expression system: Spodoptera frugiperda