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Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Benzamidine (S434A-T475A-K505 Mutant)

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.27: Coagulation factor XIa

Reaction catalysed:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Systematic name:
-
Alternative Name(s):
  • Activated blood-coagulation factor XI
  • Activated plasma thromboplastin antecedent
  • Blood-coagulation factor XIa
  • Plasma thromboplastin antecedent

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Coagulation factor XIa light chain
The deposited structure of PDB entry 1zhp contains 1 copy of Pfam domain PF00089 (Trypsin) in Coagulation factor XIa light chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Coagulation factor XIa light chain
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Coagulation factor XIa light chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Coagulation factor XIa light chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Coagulation factor XIa light chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Coagulation factor XIa light chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Coagulation factor XIa light chain

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Coagulation factor XIa light chain
The deposited structure of PDB entry 1zhp contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Coagulation factor XIa light chain. Showing 2 copies in chain A.

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