› 1zhb

X-ray diffraction
2.7Å resolution

Crystal Structure Of The Murine Class I Major Histocompatibility Complex Of H-2Db, B2-Microglobulin, and a 9-Residue Peptide Derived from rat dopamine beta-monooxigenase

Released:
DOI: 10.2210/pdb1zhb/pdb
PDB entry 1zhb coloured by chain, front view.
PDB entry 1zhb coloured by chain, side view.
PDB entry 1zhb coloured by chain, top view.
Source organisms:
Primary publication:
A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.
Sandalova T, Michaëlsson J, Harris RA, Odeberg J, Schneider G, Kärre K, Achour A
J Biol Chem 280 27069-75 (2005)
PMID: 15845547

Function and Biology Details

Reaction catalysed: 
3,4-dihydroxyphenethylamine + 2 ascorbate + O(2) = noradrenaline + 2 monodehydroascorbate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135016 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, D-B alpha chain Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 276 amino acids
Theoretical weight: 32.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01899 (Residues: 25-300; Coverage: 82%)
Gene name: H2-D1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Soluble dopamine beta-hydroxylase Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: Q05754 (Residues: 556-564; Coverage: 2%)
Gene name: Dbh

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21
Unit cell:
a: 92.063Å b: 122.715Å c: 99.403Å
α: 90° β: 103° γ: 90°
R-values:
R R work R free
0.226 0.225 0.262
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

16 citation in other articles

An altered T cell repertoire in MECL-1-deficient mice.
Basler et al. (2006)
15 more

2 mentions without citation

Structural mechanism for sterol sensing and transport by OSBP-related proteins.
Im et al. (2005)
1 more