PDBe 1zh7

X-ray diffraction
2.5Å resolution

Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 5 group A member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 243 amino acids
Theoretical weight: 28.2 KDa
Source organism: Mus musculus
  • Canonical: P45448 (Residues: 318-560; Coverage: 43%)
Gene names: Lrh1, Nr5a2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor subfamily 0 group B member 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.25 KDa
Source organism: Rattus norvegicus
  • Canonical: P97947 (Residues: 16-26; Coverage: 4%)
Gene names: Nr0b2, Shp

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: C2
Unit cell:
a: 113.765Å b: 35.126Å c: 134.205Å
α: 90° β: 92.61° γ: 90°
R R work R free
0.226 0.226 0.285