PDBe 1zfp

X-ray diffraction
1.8Å resolution

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 2 Chain: E
Molecule details ›
Chain: E
Length: 98 amino acids
Theoretical weight: 11.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 56-153; Coverage: 45%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein
EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE Chain: I
Molecule details ›
Chain: I
Length: 7 amino acids
Theoretical weight: 863 Da
Source organism: Unidentified
Expression system: Not provided

Ligands and Environments

1 bound ligand:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: C2221
Unit cell:
a: 49.9Å b: 113.7Å c: 46.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 not available not available
Expression systems:
  • Escherichia coli
  • Not provided