PDBe 1zbj

Solution NMR

Inferential Structure Determination of the Fyn SH3 domain using NOESY data from a 15N,H2 enriched protein

Released:
Source organism: Homo sapiens
Primary publication:
Inferential structure determination.
Science 309 303-6 (2005)
PMID: 16002620

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06241 (Residues: 84-142; Coverage: 11%)
Gene name: FYN
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Inferential Structure Determination, Markov Chain Monte Carlo Sampling, Replica-exchange Monte Carlo, Gibbs sampling, Hybrid Monte Carlo, Torsion angle dynamics
Expression system: Escherichia coli