› › Function and Biology

Crystal Structure of A.fulgidus Rio2 Kinase Complexed With ADP and Manganese Ions

Source organism: Archaeoglobus fulgidus
Biochemical function: protein serine kinase activity
Biological process: maturation of SSU-rRNA
Cellular component: preribosome, small subunit precursor

Quick links

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01163
Domain description: RIO1 family
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
The deposited structure of PDB entry 1zar contains 1 copy of Pfam domain PF01163 (RIO1 family) in RIO-type serine/threonine-protein kinase Rio2. Showing 1 copy in chain A.

PF09202
Domain description: Rio2, N-terminal
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
The deposited structure of PDB entry 1zar contains 1 copy of Pfam domain PF09202 (Rio2, N-terminal) in RIO-type serine/threonine-protein kinase Rio2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008266
Domain description: Tyrosine-protein kinase, active site
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
IPR000687
Domain description: RIO kinase
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
IPR015285
Domain description: RIO2 kinase winged helix domain, N-terminal
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
The deposited structure of PDB entry 1zar contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in RIO-type serine/threonine-protein kinase Rio2. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
The deposited structure of PDB entry 1zar contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in RIO-type serine/threonine-protein kinase Rio2. Showing 1 copy in chain A.
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
The deposited structure of PDB entry 1zar contains 1 copy of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in RIO-type serine/threonine-protein kinase Rio2. Showing 1 copy in chain A.
SCOP SCOP annotations
111204
Class: Alpha and beta proteins (a+b)
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
The deposited structure of PDB entry 1zar contains 1 copy of SCOP domain 111204 (RIO1-like kinases) in RIO-type serine/threonine-protein kinase Rio2. Showing 1 copy in chain A.
109702
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. RIO-type serine/threonine-protein kinase Rio2
The deposited structure of PDB entry 1zar contains 1 copy of SCOP domain 109702 (Rio2 serine protein kinase N-terminal domain) in RIO-type serine/threonine-protein kinase Rio2. Showing 1 copy in chain A.

Quick links