PDBe 1z9h

X-ray diffraction
2.6Å resolution

Microsomal prostaglandin E synthase type-2

Released:

Function and Biology Details

Reaction catalysed:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin E synthase 2 truncated form Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 290 amino acids
Theoretical weight: 33.15 KDa
Source organism: Macaca fascicularis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9N0A4 (Residues: 88-377; Coverage: 77%)
Gene names: PGES2, PTGES2, QccE-11222
Sequence domains: Glutathione S-transferase, N-terminal domain
Structure domains: Glutaredoxin

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 128.24Å b: 122.83Å c: 111.53Å
α: 90° β: 110.6° γ: 90°
R-values:
R R work R free
0.215 0.214 0.251
Expression system: Escherichia coli