PDBe 1z95

X-ray diffraction
1.8Å resolution

Crystal Structure of the Androgen Receptor Ligand-binding Domain W741L Mutant Complex with R-bicalutamide

Source organism: Homo sapiens
Primary publication:
Structural basis for antagonism and resistance of bicalutamide in prostate cancer.
Proc. Natl. Acad. Sci. U.S.A. 102 6201-6 (2005)
PMID: 15833816

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10275 (Residues: 673-918; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 56.49Å b: 66.47Å c: 72.16Å
α: 90° β: 90° γ: 90°
R R work R free
0.223 0.223 0.256
Expression system: Escherichia coli