Function and Biology

structure of interleukin-2 with its alpha receptor

Source organism: Homo sapiens
Biochemical function: interleukin-2 binding
Biological process: regulation of CD4-positive, alpha-beta T cell proliferation
Cellular component: extracellular space

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00084
Domain description: Sushi repeat (SCR repeat)
Occurring in:
  1. Interleukin-2 receptor subunit alpha
The deposited structure of PDB entry 1z92 contains 1 copy of Pfam domain PF00084 (Sushi repeat (SCR repeat)) in Interleukin-2 receptor subunit alpha. Showing 1 copy in chain B.

PF00715
Domain description: Interleukin 2
Occurring in:
  1. Interleukin-2
The deposited structure of PDB entry 1z92 contains 1 copy of Pfam domain PF00715 (Interleukin 2) in Interleukin-2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000779
Domain description: Interleukin-2
Occurring in:
  1. Interleukin-2
IPR000436
Domain description: Sushi/SCR/CCP domain
Occurring in:
  1. Interleukin-2 receptor subunit alpha
IPR035976
Domain description: Sushi/SCR/CCP superfamily
Occurring in:
  1. Interleukin-2 receptor subunit alpha
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Interleukin-2
IPR015486
Domain description: Interleukin-2 receptor alpha
Occurring in:
  1. Interleukin-2 receptor subunit alpha
IPR030477
Domain description: Interleukin-2, conserved site
Occurring in:
  1. Interleukin-2

Structure domains

CATH CATH domains
2.10.70.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Complement Module; domain 1
Homology: Complement Module, domain 1
Occurring in:
  1. Interleukin-2 receptor subunit alpha
The deposited structure of PDB entry 1z92 contains 1 copy of CATH domain 2.10.70.10 (Complement Module; domain 1) in Interleukin-2 receptor subunit alpha. Showing 1 copy in chain B.
2.20.28.230
Class: Mainly Beta
Architecture: Single Sheet
Topology: Rubrerythrin, domain 2
Homology: Rubrerythrin, domain 2
Occurring in:
  1. Interleukin-2 receptor subunit alpha
The deposited structure of PDB entry 1z92 contains 1 copy of CATH domain 2.20.28.230 (Rubrerythrin, domain 2) in Interleukin-2 receptor subunit alpha. Showing 1 copy in chain B.
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Interleukin-2
The deposited structure of PDB entry 1z92 contains 1 copy of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interleukin-2. Showing 1 copy in chain A.
SCOP SCOP annotations
57536
Class: Small proteins
Fold: Complement control module/SCR domain
Superfamily: Complement control module/SCR domain
Occurring in:
  1. Interleukin-2 receptor subunit alpha
The deposited structure of PDB entry 1z92 contains 2 copies of SCOP domain 57536 (Complement control module/SCR domain) in Interleukin-2 receptor subunit alpha. Showing 2 copies in chain B.
47286
Class: All alpha proteins
Fold: 4-helical cytokines
Superfamily: 4-helical cytokines
Occurring in:
  1. Interleukin-2
The deposited structure of PDB entry 1z92 contains 1 copy of SCOP domain 47286 (Short-chain cytokines) in Interleukin-2. Showing 1 copy in chain A.