› 1z5r

X-ray diffraction
1.4Å resolution

Crystal Structure of Activated Porcine Pancreatic Carboxypeptidase B

Released:
DOI: 10.2210/pdb1z5r/pdb
PDB entry 1z5r coloured by chain, front view.
PDB entry 1z5r coloured by chain, side view.
PDB entry 1z5r coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase B.
Adler M, Bryant J, Buckman B, Islam I, Larsen B, Finster S, Kent L, May K, Mohan R, Yuan S, Whitlow M
Biochemistry 44 9339-47 (2005)
PMID: 15982000

Function and Biology Details

Reaction catalysed: 
Preferential release of a C-terminal lysine or arginine amino acid.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase B Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 306 amino acids
Theoretical weight: 34.74 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P09955 (Residues: 111-416; Coverage: 76%)
Gene names: CPB, CPB1
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 66.815Å b: 96.055Å c: 135.821Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.175 0.209

Quick links

Citations

2 review citations

Opportunities for structure-based design of protease-directed drugs.
Mittl et al. (2006)
1 more

2 mentions without citation

Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
Schreuder et al. (2016)
1 more