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Crystal Structure of Bovine Low Molecular Weight PTPase Complexed with Vanadate

X-ray diffraction
2.2Å resolution
PDB entry 1z12 coloured by chain, front view.
PDB entry 1z12 coloured by chain, side view.
PDB entry 1z12 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Low molecular weight phosphotyrosine protein phosphatase
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Multimeric state: monomeric
Accessible surface area: 8194.06 Å2
Buried surface area: 225.55 Å2
Dissociation area: 112.77 Å2
Dissociation energy (ΔGdiss): 3.05 kcal/mol
Dissociation entropy (TΔSdiss): 0.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145642

Macromolecules

Low molecular weight phosphotyrosine protein phosphatase
Chain: A
Length: 157 amino acids
Theoretical weight: 17.95 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11064 (Residues: 2-158; Coverage: 99%)
Gene name: ACP1
Pfam: Low molecular weight phosphotyrosine protein phosphatase
InterPro:
CATH: Rossmann fold
SCOP: Low-molecular-weight phosphotyrosine protein phosphatases
Low molecular weight phosphotyrosine protein phosphatase in PDB entry 1z12, assembly 1, front view.
Low molecular weight phosphotyrosine protein phosphatase in PDB entry 1z12, assembly 1, side view.
Low molecular weight phosphotyrosine protein phosphatase in PDB entry 1z12, assembly 1, top view.
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