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Phospholipase Cgamma1 SH3 in complex with a SLP-76 motif

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.4.11: Phosphoinositide phospholipase C

Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Systematic name:
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
Alternative Name(s):
  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
  • Monophosphatidylinositol phosphodiesterase
  • PI-PLC
  • Phosphatidylinositol phospholipase C
  • Phosphoinositidase C
  • Triphosphoinositide phosphodiesterase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00018
Domain description: SH3 domain
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
The deposited structure of PDB entry 1ywo contains 1 copy of Pfam domain PF00018 (SH3 domain) in 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001452
Domain description: SH3 domain
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
IPR035724
Domain description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Structure domain

CATH CATH domain
2.30.30.40
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 Domains
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
The deposited structure of PDB entry 1ywo contains 1 copy of CATH domain 2.30.30.40 (SH3 type barrels.) in 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1. Showing 1 copy in chain A.

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