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Structure of Unphosphorylated STAT1

X-ray diffraction
3Å resolution
PDB entry 1yvl coloured by chain, front view.
PDB entry 1yvl coloured by chain, side view.
PDB entry 1yvl coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero octamer
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Signal transducer and activator of transcription 1-alpha/beta and peptide
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Multimeric state: hetero dimer
Accessible surface area: 34393.22 Å2
Buried surface area: 1103.95 Å2
Dissociation area: 491.42 Å2
Dissociation energy (ΔGdiss): 5.2 kcal/mol
Dissociation entropy (TΔSdiss): 6.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154568
Assembly 2
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Assembly Name: Signal transducer and activator of transcription 1-alpha/beta and peptide
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Multimeric state: hetero dimer
Accessible surface area: 34123.24 Å2
Buried surface area: 1090.09 Å2
Dissociation area: 483.94 Å2
Dissociation energy (ΔGdiss): 6.51 kcal/mol
Dissociation entropy (TΔSdiss): 6.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154568
Assembly 3
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Assembly Name: Signal transducer and activator of transcription 1-alpha/beta and peptide
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Multimeric state: hetero octamer
Accessible surface area: 125341.13 Å2
Buried surface area: 16089.51 Å2
Dissociation area: 2,314.77 Å2
Dissociation energy (ΔGdiss): 1.89 kcal/mol
Dissociation entropy (TΔSdiss): 17.73 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154570
Assembly 4
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Assembly Name: STAT1 homodimer and peptide
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Multimeric state: hetero tetramer
Accessible surface area: 64980.61 Å2
Buried surface area: 5735.49 Å2
Dissociation area: 1,769.71 Å2
Dissociation energy (ΔGdiss): 2.23 kcal/mol
Dissociation entropy (TΔSdiss): 15.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154569

Macromolecules

Signal transducer and activator of transcription 1-alpha/beta
Chains: A, B
Length: 683 amino acids
Theoretical weight: 80.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42224 (Residues: 1-683; Coverage: 91%)
Gene name: STAT1
Pfam:
InterPro:
CATH:
Signal transducer and activator of transcription 1-alpha/beta in PDB entry 1yvl, assembly 1, front view.
Signal transducer and activator of transcription 1-alpha/beta in PDB entry 1yvl, assembly 1, side view.
Signal transducer and activator of transcription 1-alpha/beta in PDB entry 1yvl, assembly 1, top view.
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5-residue peptide
Chains: C, D
Length: 5 amino acids
Theoretical weight: 741 Da
Source organism: Homo sapiens
Expression system: Not provided
5-residue peptide in PDB entry 1yvl, assembly 1, front view.
5-residue peptide in PDB entry 1yvl, assembly 1, side view.
5-residue peptide in PDB entry 1yvl, assembly 1, top view.
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