PDBe 1yvj

X-ray diffraction
2.55Å resolution

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK3 Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52333 (Residues: 814-1103; Coverage: 26%)
Gene name: JAK3
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 46.307Å b: 54.215Å c: 118.607Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.254
Expression system: Escherichia coli