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the Plasmodium falciparum Cysteine Protease Falcipain-2

X-ray diffraction
2.7Å resolution
PDB entry 1yvb coloured by chain, front view.
PDB entry 1yvb coloured by chain, side view.
PDB entry 1yvb coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cystatin and Falcipain-2a
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Multimeric state: hetero dimer
Accessible surface area: 17188.07 Å2
Buried surface area: 1923.38 Å2
Dissociation area: 869.29 Å2
Dissociation energy (ΔGdiss): 4.2 kcal/mol
Dissociation entropy (TΔSdiss): 11.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-223070

Macromolecules

Falcipain-2a
Chain: A
Length: 241 amino acids
Theoretical weight: 27.19 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I6U4 (Residues: 244-484; Coverage: 50%)
Gene names: FP-2, FP2, FP2A, PF3D7_1115700
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
SCOP: Papain-like
Cysteine proteinase falcipain 2a in PDB entry 1yvb, assembly 1, front view.
Cysteine proteinase falcipain 2a in PDB entry 1yvb, assembly 1, side view.
Cysteine proteinase falcipain 2a in PDB entry 1yvb, assembly 1, top view.
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Cystatin
Chain: I
Length: 111 amino acids
Theoretical weight: 12.59 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P01038 (Residues: 29-139; Coverage: 96%)
Pfam: Cystatin domain
InterPro:
CATH: Nuclear Transport Factor 2; Chain: A,
SCOP: Cystatins
Cystatin in PDB entry 1yvb, assembly 1, front view.
Cystatin in PDB entry 1yvb, assembly 1, side view.
Cystatin in PDB entry 1yvb, assembly 1, top view.
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