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Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate

Source organism: Escherichia coli
Biochemical function: NADP binding
Biological process: pantothenate biosynthetic process
Cellular component: cytoplasm

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EC 1.1.1.169: 2-dehydropantoate 2-reductase

Reaction catalysed:
(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH
Systematic name:
(R)-pantoate:NADP(+) 2-oxidoreductase
Alternative Name(s):
  • 2-ketopantoate reductase
  • 2-ketopantoic acid reductase
  • 2-oxopantoate reductase
  • KPA reductase
  • Ketopantoate reductase
  • Ketopantoic acid reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08546
Domain description: Ketopantoate reductase PanE/ApbA C terminal
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 1yon contains 1 copy of Pfam domain PF08546 (Ketopantoate reductase PanE/ApbA C terminal) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.

PF02558
Domain description: Ketopantoate reductase PanE/ApbA
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 1yon contains 1 copy of Pfam domain PF02558 (Ketopantoate reductase PanE/ApbA) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013752
Domain description: Ketopantoate reductase, C-terminal domain
Occurring in:
  1. 2-dehydropantoate 2-reductase
IPR013328
Domain description: 6-phosphogluconate dehydrogenase, domain 2
Occurring in:
  1. 2-dehydropantoate 2-reductase
IPR008927
Domain description: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Occurring in:
  1. 2-dehydropantoate 2-reductase
IPR013332
Domain description: Ketopantoate reductase, N-terminal domain
Occurring in:
  1. 2-dehydropantoate 2-reductase
IPR003710
Domain description: Ketopantoate reductase ApbA/PanE
Occurring in:
  1. 2-dehydropantoate 2-reductase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 2-dehydropantoate 2-reductase

Structure domains

CATH CATH domains
1.10.1040.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homology: N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 1yon contains 1 copy of CATH domain 1.10.1040.10 (N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 1yon contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.
SCOP SCOP annotations
69084
Class: All alpha proteins
Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like
Superfamily: 6-phosphogluconate dehydrogenase C-terminal domain-like
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 1yon contains 1 copy of SCOP domain 69084 (Ketopantoate reductase PanE) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.
51868
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 1yon contains 1 copy of SCOP domain 51868 (6-phosphogluconate dehydrogenase-like, N-terminal domain) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.

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