Structure analysis

Crystal structure of Src kinase domain in complex with Purvalanol A

X-ray diffraction
2.9Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 13300 Å2
Buried surface area: 800 Å2
Dissociation area: 400 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -2 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 13400 Å2
Buried surface area: 750 Å2
Dissociation area: 400 Å2
Dissociation energy (ΔGdiss): -4 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 283 amino acids
Theoretical weight: 32.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12931 (Residues: 254-536; Coverage: 53%)
Gene names: SRC, SRC1
Pfam: Protein tyrosine kinase
InterPro:
CATH:

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