› 1yn7

X-ray diffraction
2.2Å resolution

Crystal structure of a mouse MHC class I protein, H2-Db, in complex with a mutated peptide (R7A) of the influenza A acid polymerase

Released:
DOI: 10.2210/pdb1yn7/pdb
PDB entry 1yn7 coloured by chain, front view.
PDB entry 1yn7 coloured by chain, side view.
PDB entry 1yn7 coloured by chain, top view.
Source organisms:
Primary publication:
Favorite flavors of surfaces.
Jones EY
Nat Immunol 6 365-6 (2005)
PMID: 15785764

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134988 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, D-B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.8 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01899 (Residues: 26-298; Coverage: 81%)
Gene name: H2-D1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Polymerase acidic protein Chain: C
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 1.1 KDa
Source organism: Influenza A virus (A/swine/Iowa/15/1930(H1N1))
Expression system: Not provided
UniProt:
  • Canonical: P13175 (Residues: 224-233; Coverage: 1%)
Gene name: PA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P43212
Unit cell:
a: 56.306Å b: 56.306Å c: 274.272Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.264
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 citation in other articles

The cytotoxic T cell response to peptide analogs of the HLA-A*0201-restricted MUC1 signal sequence epitope, M1.2.
Mitchell et al. (2007)
1 more

3 mentions without citation

Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy.
Kedzierska et al. (2008)
2 more