PDBe 1ykc

X-ray diffraction
2.1Å resolution

human glutathione S-transferase m2-2 (E.C.2.5.1.18) complexed with glutathione-disulfide

Released:
Source organism: Homo sapiens
Entry authors: Patskovsky YV, Patskovska LN, Listowsky I, Almo SC

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase Mu 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 217 amino acids
Theoretical weight: 25.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28161 (Residues: 2-218; Coverage: 100%)
Gene names: GST4, GSTM2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 56.61Å b: 74.79Å c: 116.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.206 0.254
Expression system: Escherichia coli BL21(DE3)