Function and Biology

NMR STRUCTURE OF RIBONUCLEASE T1, 34 STRUCTURES

Source organism: Aspergillus oryzae
Biochemical function: ribonuclease T1 activity
Biological process: biological_process
Cellular component: cell septum

EC 4.6.1.24: Ribonuclease T(1)

Reaction catalysed:
(1a) (RNA) containing guanosine = (RNA fragment)-3'-guanosine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA fragment)
Systematic name:
(RNA)-guanosine 5'-hydroxy-ribonucleotide-3'-(RNA fragment)-lyase (cyclicizing; (RNA fragment)-3'-guanosine-2',3'-cyclophosphate-forming and hydrolyzing)
Alternative Name(s):
  • Aspergillus oryzae ribonuclease
  • Binase
  • Guanyl-specific RNase
  • Guanyloribonuclease
  • RNase F(1)
  • RNase G
  • RNase N(1)
  • RNase N(2)
  • RNase Sa
  • RNase T(1)
  • Ribonuclease C2
  • Ribonuclease Ch
  • Ribonuclease F(1)
  • Ribonuclease N(1)
  • Ribonuclease N(3)
  • Ribonuclease PP1
  • Ribonuclease SA
  • Ribonuclease T1
  • Ribonuclease U(1)
  • Ribonuclease guaninenucleotido-2'-transferase (cyclizing)

Sequence family

InterPro InterPro annotations
IPR000026
Domain description: Guanine-specific ribonuclease Sa-like
Occurring in:
  1. Guanyl-specific ribonuclease T1
IPR016191
Domain description: Ribonuclease/ribotoxin
Occurring in:
  1. Guanyl-specific ribonuclease T1

Structure domain

CATH CATH domain
3.10.450.30
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Microbial ribonucleases
Occurring in:
  1. Guanyl-specific ribonuclease T1
The deposited structure of PDB entry 1ygw contains 1 copy of CATH domain 3.10.450.30 (Nuclear Transport Factor 2; Chain: A,) in Guanyl-specific ribonuclease T1. Showing 1 copy in chain A.
SCOP SCOP annotation
81311
Class: Alpha and beta proteins (a+b)
Fold: Microbial ribonucleases
Superfamily: Microbial ribonucleases
Occurring in:
  1. Guanyl-specific ribonuclease T1
The deposited structure of PDB entry 1ygw contains 1 copy of SCOP domain 81311 (Fungal ribonucleases) in Guanyl-specific ribonuclease T1. Showing 1 copy in chain A.