PDBe 1yah

X-ray diffraction
3Å resolution

Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue

Released:

Function and Biology Details

Reactions catalysed:
A carboxylic ester + H(2)O = an alcohol + a carboxylate
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Liver carboxylesterase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 532 amino acids
Theoretical weight: 58.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23141 (Residues: 21-553; Coverage: 97%)
  • Best match: P23141-3 (Residues: 21-552)
Gene names: CES1, CES2, SES1
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 55.5Å b: 181.15Å c: 203.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.229
Expression system: Spodoptera frugiperda