PDBe 1ya5

X-ray diffraction
2.44Å resolution

Crystal structure of the titin domains z1z2 in complex with telethonin

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Telethonin Chain: T
Molecule details ›
Chain: T
Length: 90 amino acids
Theoretical weight: 10.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15273 (Residues: 1-90; Coverage: 54%)
Gene name: TCAP
Structure domains: titin domain like
Titin Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 21.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WZ42 (Residues: 1-196; Coverage: 1%)
Gene name: TTN
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P212121
Unit cell:
a: 46.326Å b: 63.213Å c: 242.584Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.232 0.265
Expression system: Escherichia coli