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Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain

X-ray diffraction
2.7Å resolution
PDB entry 1y6n coloured by chain, front view.
PDB entry 1y6n coloured by chain, side view.
PDB entry 1y6n coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-10 receptor subunit alpha and Viral interleukin-10 homolog
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Multimeric state: hetero tetramer
Accessible surface area: 32903.64 Å2
Buried surface area: 12824.59 Å2
Dissociation area: 2,053 Å2
Dissociation energy (ΔGdiss): -15.71 kcal/mol
Dissociation entropy (TΔSdiss): 26.23 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136628

Macromolecules

Viral interleukin-10 homolog
Chain: L
Length: 145 amino acids
Theoretical weight: 17.44 KDa
Source organism: human gammaherpesvirus 4
Expression system: Escherichia coli
UniProt:
  • Canonical: P03180 (Residues: 26-170; Coverage: 99%)
Gene name: BCRF1
Pfam: Interleukin 10
InterPro:
CATH: Growth Hormone; Chain: A;
SCOP: Interferons/interleukin-10 (IL-10)
Viral interleukin-10 homolog in PDB entry 1y6n, assembly 1, front view.
Viral interleukin-10 homolog in PDB entry 1y6n, assembly 1, side view.
Viral interleukin-10 homolog in PDB entry 1y6n, assembly 1, top view.
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Interleukin-10 receptor subunit alpha
Chain: R
Length: 214 amino acids
Theoretical weight: 24.51 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q13651 (Residues: 22-235; Coverage: 38%)
Gene names: IL10R, IL10RA
Pfam: Tissue factor
InterPro:
CATH: Immunoglobulins
SCOP: Fibronectin type III
Interleukin-10 receptor subunit alpha in PDB entry 1y6n, assembly 1, front view.
Interleukin-10 receptor subunit alpha in PDB entry 1y6n, assembly 1, side view.
Interleukin-10 receptor subunit alpha in PDB entry 1y6n, assembly 1, top view.
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