PDBe 1y6k

X-ray diffraction
2.52Å resolution

Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-10 Chain: L
Molecule details ›
Chain: L
Length: 160 amino acids
Theoretical weight: 18.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P22301 (Residues: 19-178; Coverage: 100%)
Gene name: IL10
Structure domains: Growth Hormone; Chain: A;
Interleukin-10 receptor subunit alpha Chain: R
Molecule details ›
Chain: R
Length: 214 amino acids
Theoretical weight: 24.51 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
  • Canonical: Q13651 (Residues: 22-235; Coverage: 38%)
Gene names: IL10R, IL10RA
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P3212
Unit cell:
a: 46.44Å b: 46.44Å c: 309.25Å
α: 90° β: 90° γ: 120°
R R work R free
0.233 0.229 0.279
Expression systems:
  • Escherichia coli BL21(DE3)
  • Drosophila melanogaster