PDBe 1y4l

X-ray diffraction
1.7Å resolution

Crystal structure of Bothrops asper myotoxin II complexed with the anti-trypanosomal drug suramin


Function and Biology Details

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Basic phospholipase A2 homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 13.76 KDa
Source organism: Bothrops asper
  • Canonical: P24605 (Residues: 17-137; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 49.199Å b: 64.037Å c: 85.99Å
α: 90° β: 90° γ: 90°
R R work R free
0.227 0.206 0.24