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Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide

X-ray diffraction
2.8Å resolution
PDB entry 1xz0 coloured by chain, front view.
PDB entry 1xz0 coloured by chain, side view.
PDB entry 1xz0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: T-cell surface glycoprotein CD1a and Beta-2-microglobulin
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Multimeric state: hetero dimer
Accessible surface area: 19785.43 Å2
Buried surface area: 5123.16 Å2
Dissociation area: 1,192.17 Å2
Dissociation energy (ΔGdiss): 6.86 kcal/mol
Dissociation entropy (TΔSdiss): 12.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138875
Assembly 2
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Assembly Name: T-cell surface glycoprotein CD1a and Beta-2-microglobulin
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Multimeric state: hetero dimer
Accessible surface area: 19860.18 Å2
Buried surface area: 4488.71 Å2
Dissociation area: 1,189.15 Å2
Dissociation energy (ΔGdiss): 8.29 kcal/mol
Dissociation entropy (TΔSdiss): 12.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138875

Macromolecules

T-cell surface glycoprotein CD1a
Chains: A, C
Length: 279 amino acids
Theoretical weight: 31.9 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P06126 (Residues: 18-294; Coverage: 89%)
Gene name: CD1A
Pfam:
InterPro:
CATH:
SCOP:
T-cell surface glycoprotein CD1a in PDB entry 1xz0, assembly 1, front view.
T-cell surface glycoprotein CD1a in PDB entry 1xz0, assembly 1, side view.
T-cell surface glycoprotein CD1a in PDB entry 1xz0, assembly 1, top view.
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Beta-2-microglobulin
Chains: B, D
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 1xz0, assembly 1, front view.
Beta-2-microglobulin in PDB entry 1xz0, assembly 1, side view.
Beta-2-microglobulin in PDB entry 1xz0, assembly 1, top view.
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