› 1xyd

Solution NMR

NMR Solution Structure of Rat Zinc-Calcium-S100B, 20 Structures

Released:
DOI: 10.2210/pdb1xyd/pdb
PDB entry 1xyd coloured by chain, ensemble of 20 models, front view.
PDB entry 1xyd coloured by chain, ensemble of 20 models, side view.
PDB entry 1xyd coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy.
Wilder PT, Varney KM, Weiss MB, Gitti RK, Weber DJ
Biochemistry 44 5690-702 (2005)
PMID: 15823027

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-B Chains: A, B
Molecule details ›
Chains: A, B
Length: 92 amino acids
Theoretical weight: 10.76 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04631 (Residues: 1-92; Coverage: 100%)
Gene name: S100b
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Escherichia coli

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Citations

5 review citations

Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes.
Vogl et al. (2012)
4 more

4 mentions without citation

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function.
Moroz et al. (2009)
3 more