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Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin

X-ray diffraction
2.91Å resolution
PDB entry 1xxd coloured by chain, front view.
PDB entry 1xxd coloured by chain, side view.
PDB entry 1xxd coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor XIa light chain and Ecotin
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Multimeric state: hetero tetramer
Accessible surface area: 33787.25 Å2
Buried surface area: 9775.71 Å2
Dissociation area: 2,785.69 Å2
Dissociation energy (ΔGdiss): 18.91 kcal/mol
Dissociation entropy (TΔSdiss): 14.64 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-137288

Macromolecules

Coagulation factor XIa light chain
Chains: A, B
Length: 238 amino acids
Theoretical weight: 26.83 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Coagulation factor XIa light chain in PDB entry 1xxd, assembly 1, front view.
Coagulation factor XIa light chain in PDB entry 1xxd, assembly 1, side view.
Coagulation factor XIa light chain in PDB entry 1xxd, assembly 1, top view.
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Ecotin
Chains: C, D
Length: 142 amino acids
Theoretical weight: 16.24 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P23827 (Residues: 21-162; Coverage: 100%)
Gene names: JW2197, b2209, eco, eti
Pfam: Ecotin
InterPro:
CATH: Ecotin
SCOP: Ecotin, trypsin inhibitor
Ecotin in PDB entry 1xxd, assembly 1, front view.
Ecotin in PDB entry 1xxd, assembly 1, side view.
Ecotin in PDB entry 1xxd, assembly 1, top view.
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