PDBe 1xww

X-ray diffraction
1.63Å resolution

Crystal Structure of Human B-form Low Molecular Weight Phosphotyrosyl Phosphatase at 1.6 Angstrom Resolution

Released:

Function and Biology Details

Reactions catalysed:
A phosphate monoester + H(2)O = an alcohol + phosphate. 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low molecular weight phosphotyrosine protein phosphatase Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P24666 (Residues: 2-158; Coverage: 99%)
  • Best match: P24666-2 (Residues: 2-158)
Gene name: ACP1
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 31.258Å b: 35.481Å c: 60.375Å
α: 90° β: 99.97° γ: 90°
R-values:
R R work R free
0.185 0.158 0.216
Expression system: Escherichia coli BL21(DE3)