PDBe 1xws

X-ray diffraction
1.8Å resolution

Crystal Structure of the human PIM1 kinase domain

Released:
Source organism: Homo sapiens
Entry authors: Knapp S, Debreczeni J, Bullock A, von Delft F, Sundstrom M, Arrowsmith C, Edwards A, Guo K

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 35.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 92-404; Coverage: 78%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P65
Unit cell:
a: 99.55Å b: 99.55Å c: 80.06Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.18 0.213
Expression system: Escherichia coli