PDBe 1xvt

X-ray diffraction
2.3Å resolution

Crystal Structure of Native CaiB in complex with coenzyme A

Released:

Function and Biology Details

Reaction catalysed:
(1) (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4- (trimethylammonio)but-2-enoate + L-carnitinyl-CoA. (2) 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-carnitine CoA-transferase Chain: A
Molecule details ›
Chain: A
Length: 408 amino acids
Theoretical weight: 46.25 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P31572 (Residues: 1-405; Coverage: 100%)
Gene names: JW0037, b0038, caiB, yaaN
Sequence domains: CoA-transferase family III
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P41212
Unit cell:
a: 87.76Å b: 87.76Å c: 164.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.237
Expression system: Escherichia coli